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Non-enzymatic glucose sensor based on the CuS nanoflakes-reduced graphene oxide nanocomposite

Abstract

In this work, Copper sulfide nanoflakes-reduced graphene oxide (rGO/CuSNFs) nanocomposite has been successfully synthesized via one-pot hydrothermal treatment, where the reduction of GO and in situ generation of CuS nanoflakes occurred simultaneously. Subsequently, a nonenzymatic electrochemical sensor was fabricated based on the disposable rGO/CuSNFs nanocomposite for highly sensitive and selective detection of glucose. The prepared rGO/CuSNFs nanocomposite was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray spectrometry (EDX), X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, respectively. Under optimized conditions, the prepared enzymeless sensor exhibited remarkable catalytic activity toward the glucose oxidation with a fast response time of <6 s, a wide linear range from 1 to 2000 μM, a high sensitivity of 53.5 μA/(cm2 mM) and a low detection limit of 0.19 μM. Furthermore, the rGO/CuSNFs/GCE also showed the great reproducibility, long-term storage stability and the excellent anti-interference ability for glucose sensing. In addition, the as-prepared sensor was applied to detect glucose in human urine and blood serum samples with satisfactory results, indicating that the rGO/CuSNFs nanocomposite is an extremely promising material for non-enzymatic glucose sensing in practical samples.

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Supplementary files

Publication details

The article was received on 26 Sep 2017, accepted on 28 Nov 2017 and first published on 04 Dec 2017


Article type: Paper
DOI: 10.1039/C7AY02290E
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Non-enzymatic glucose sensor based on the CuS nanoflakes-reduced graphene oxide nanocomposite

    X. Yan, Y. Gu, C. Li, B. Zheng, Y. Li, T. Zhang, Z. Zhang and M. Yang, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY02290E

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