Jump to main content
Jump to site search

Issue 47, 2017
Previous Article Next Article

A chemiluminescence method for the determination of verapamil hydrochloride in pharmaceutical and environmental samples based on an Fe3O4 nanoparticles enhanced NaHCO3–H2O2 system

Author affiliations

Abstract

In this work, an Fe3O4 nanoparticles (NPs)-enhanced chemiluminescence (CL) method was developed for the determination of verapamil hydrochloride (VRP). To this aim, a quick precipitation method was employed to synthesize Fe3O4 NPs. The synthesised Fe3O4 NPs were then characterized by using techniques including Fourier Transform Infrared (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). It was found that the Fe3O4 NPs were able to enhance the NaHCO3–H2O2 CL reaction. In addition, it was shown that VRP had an inhibitory effect on the Fe3O4 NPs–NaHCO3–H2O2 system in such a way that the CL intensity was inversely proportional to the concentration of VRP. These findings were used for the establishment of a new, green, simple and sensitive CL analytical method for VRP with a linear dynamic range of 5.0 × 10−6 to 1.0 × 10−3 mol L−1, a correlation coefficient (r2) of 0.99 and a limit of detection of 2.8 × 10−6 mol L−1. The CL method was successfully used for the determination of VRP in pharmaceutical formulations.

Graphical abstract: A chemiluminescence method for the determination of verapamil hydrochloride in pharmaceutical and environmental samples based on an Fe3O4 nanoparticles enhanced NaHCO3–H2O2 system

Back to tab navigation

Publication details

The article was received on 11 Sep 2017, accepted on 11 Nov 2017 and first published on 13 Nov 2017


Article type: Paper
DOI: 10.1039/C7AY02164J
Citation: Anal. Methods, 2017,9, 6705-6712
  •   Request permissions

    A chemiluminescence method for the determination of verapamil hydrochloride in pharmaceutical and environmental samples based on an Fe3O4 nanoparticles enhanced NaHCO3–H2O2 system

    M. Iranifam and N. R. Hendekhale, Anal. Methods, 2017, 9, 6705
    DOI: 10.1039/C7AY02164J

Search articles by author

Spotlight

Advertisements