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A chemiluminescence method for the determination of verapamil hydrochloride in pharmaceutical and environmental samples based on Fe3O4 nanoparticles enhanced NaHCO3- H2O2 system

Abstract

In this work, Fe3O4 nanoparticles (NPs) - enhanced chemiluminescence (CL) method was developed for determination of verapamil hydrochloride (VRP). To this aim, a quick precipitation method was employed to synthesis of Fe3O4 NPs. The synthesised Fe3O4 NPs were then characterized by using techniques including Fourier Transform Infrared (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM). It was found that Fe3O4 NPs were able to enhance NaHCO3 - H2O2 CL reaction. In addition, it was shown that VRP possessed inhibitory effect on the Fe3O4 NPs- NaHCO3-H2O2 system in such way that the CL intensity was inversely proportional to the concentration of VRP. These findings were used for establishment of a new, green, simple and sensitive CL analytical method for VRP with linear dynamic range of 5.0 × 10-6 – 1.0 × 10-3 mol L-1, correlation coefficient (r2) of 0.99 and limit of detection of 2.8 × 10-6 mol L-1. The CL method was successfully used for determination of VRP in pharmaceutical formulation.

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Publication details

The article was received on 11 Sep 2017, accepted on 11 Nov 2017 and first published on 13 Nov 2017


Article type: Paper
DOI: 10.1039/C7AY02164J
Citation: Anal. Methods, 2017, Accepted Manuscript
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    A chemiluminescence method for the determination of verapamil hydrochloride in pharmaceutical and environmental samples based on Fe3O4 nanoparticles enhanced NaHCO3- H2O2 system

    M. Iranifam and N. Rahmati Hendekhale, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY02164J

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