Jump to main content
Jump to site search


Simultaneous determination of bisphenol A and tetrabromobisphenol A in tea using a modified QuEChERS sample preparation method coupled with liquid chromatography-tandem mass spectrometry

Author affiliations

Abstract

A rapid and sensitive method for the simultaneous determination of bisphenol A (BPA) and tetrabromobisphenol A (TBBPA) in tea using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated. Sample preparation was based on a modified QuEChERS procedure through extraction of the target analytes using acetonitrile with 0.7% acetic acid followed by a dispersive solid phase extraction (d-SPE) clean up procedure using C18, MWCNTs and SCX as the adsorbent mixture to eliminate tea co-extracts. The linearity of the method with correlation coefficients (R2) higher than 0.99 was obtained. The limits of detection (LODs), and limits of quantitation (LOQs) were 8.0 and 20.0 μg kg−1 for BPA and 0.4 and 1.0 μg kg−1 for TBBPA, respectively. Satisfactory mean recoveries of BPA and TBBPA at three fortification levels ranged from 88% to 109% and 77% to 99%, respectively, while intra-day and inter-day precisions were below 15%. The developed method was successfully applied to determine BPA and TBPA in 136 tea samples.

Graphical abstract: Simultaneous determination of bisphenol A and tetrabromobisphenol A in tea using a modified QuEChERS sample preparation method coupled with liquid chromatography-tandem mass spectrometry

Back to tab navigation

Publication details

The article was received on 06 Sep 2017, accepted on 20 Oct 2017 and first published on 23 Oct 2017


Article type: Paper
DOI: 10.1039/C7AY02145C
Citation: Anal. Methods, 2017, Advance Article
  •   Request permissions

    Simultaneous determination of bisphenol A and tetrabromobisphenol A in tea using a modified QuEChERS sample preparation method coupled with liquid chromatography-tandem mass spectrometry

    G. Gao, H. Chen, L. Zhu, Y. Chai, G. Ma, C. Wang, Z. Hao, X. Liu and C. Lu, Anal. Methods, 2017, Advance Article , DOI: 10.1039/C7AY02145C

Search articles by author

Spotlight

Advertisements