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Simultaneous determination of bisphenol A and tetrabromobisphenol A in tea using a modified QuEChERS sample preparation method coupled with liquid chromatography–tandem mass spectrometry

Abstract

A rapid and sensitive method for the simultaneous determination of bisphenol A (BPA) and tetrabromobisphenol A (TBBPA) in tea using liquid chromatography–tandem mass spectrometry (LC-MS/MS) was developed and validated. Sample preparation was based on a modified QuEChERS procedure through an extraction of target analytes using acetonitrile with 0.7% acetate acid followed by dispersive solid phase extraction (d-SPE) clean up procedure using C18, MWCNTs and SCX as adsorbent mixture to eliminate tea co-extracts. The linearity of the method with correlation coefficients (R2) higher than 0.99 was obtained. The limits of detection (LODs), and limits of quantitation (LOQs) were 8.0 and 20.0 μg kg-1 for BPA, 0.4 and 1.0 μg kg-1 for TBBPA, respectively. Satisfactory mean recoveries of BPA and TBBPA at three fortification levels ranged from 88% to 109% and 77% to 99%, respectively, while intra and inter-day precisions were below 15%. The developed method was successfully applied to determine BPA and TBPA in 136 tea samples.

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Publication details

The article was received on 06 Sep 2017, accepted on 20 Oct 2017 and first published on 23 Oct 2017


Article type: Paper
DOI: 10.1039/C7AY02145C
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Simultaneous determination of bisphenol A and tetrabromobisphenol A in tea using a modified QuEChERS sample preparation method coupled with liquid chromatography–tandem mass spectrometry

    G. Gao, H. Chen, L. Zhu, Y. Chai, G. Ma, C. Wang , Z. Hao, X. Liu and C. Lu, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY02145C

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