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Determination of (S)-warfarin using an activated screen printed gold electrode modified with gold nanoparticles and an enantioselective molecularly imprinted polymer

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Abstract

In this work a novel and simple electrochemical sensor for the determination of (S)-warfarin based on an activated screen printed gold/Au nanoparticles/molecularly imprinted polymer electrode (ASPG/AuNPs/MIP) was introduced. Cyclic voltammetry, differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy were used to investigate the electrochemical behavior of (S)-warfarin at the modified electrode under optimum conditions. According to the results, ASPG/AuNPs/MIP showed a linear range for (S)-warfarin concentrations from 5.0 nM to 1.0 μM and a limit of detection of 1.0 nM by DPV. The proposed sensor was used for the determination of (S)-warfarin in commercial tablets, human serum and urine with satisfactory results.

Graphical abstract: Determination of (S)-warfarin using an activated screen printed gold electrode modified with gold nanoparticles and an enantioselective molecularly imprinted polymer

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Publication details

The article was received on 23 Aug 2017, accepted on 31 Oct 2017 and first published on 31 Oct 2017


Article type: Paper
DOI: 10.1039/C7AY02031G
Citation: Anal. Methods, 2017, Advance Article
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    Determination of (S)-warfarin using an activated screen printed gold electrode modified with gold nanoparticles and an enantioselective molecularly imprinted polymer

    I. Yawari and M. Kaykhaii, Anal. Methods, 2017, Advance Article , DOI: 10.1039/C7AY02031G

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