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Characterization of the major chemical constituents in Ardisia Gigantifolia by high performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry

Abstract

The dried root of Ardisia gigantifolia Stapf. (RAG) is mainly used as a chinese folk medicine. A clear understanding of the major components is very important in their rational clinical use and pharmacological research. To find more of the major components in RAG, a high performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight–mass spectrometry method (HPLC-ESI-QTOF–MS/MS) was proposed. The components were characterised based on their accurate mass and MS/MS data provided by the QTOF–MS as well as by comparison with information from the literature. In this study, 27 phytochemical components were tentatively characterised. Notably, out of the 27 components, 8 triterpenoid saponins are new and their chemical structures have been proposed for the first time in RAG. These results showed that the HPLC-ESI-QTOF–MS/MS method was a powerful tool for a comprehensive research of RAG, which could provide a meaningful basis for further quality control, pharmacological as well as toxicological researches.

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Publication details

The article was received on 17 Aug 2017, accepted on 06 Sep 2017 and first published on 07 Sep 2017


Article type: Paper
DOI: 10.1039/C7AY01983A
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Characterization of the major chemical constituents in Ardisia Gigantifolia by high performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry

    Z. Chen, Y. Ling, Q. Zhang and H. Wan, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY01983A

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