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Spiegelmers as potential receptors for cTnI diagnostics

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Abstract

We demonstrate the first application of a nuclease resistant aptamer, the so-called Spiegelmer, in a sandwich-type affinity assay by quantitative assessment of cardiac Troponin I (cTnI) in blood serum samples. To this end, we used a bead-based homogenous proximity assay (AlphaLISA) in which luminescence is generated by the Spiegelmer and antibody-modified donor and acceptor beads brought into proximity by their binding to cTnI.

Graphical abstract: Spiegelmers as potential receptors for cTnI diagnostics

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Publication details

The article was received on 21 Jul 2017, accepted on 24 Jul 2017 and first published on 28 Jul 2017


Article type: Communication
DOI: 10.1039/C7AY01777D
Citation: Anal. Methods, 2017, Advance Article
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    Spiegelmers as potential receptors for cTnI diagnostics

    Z. Szeitner, A. Doleschall, M. Varga, K. Keltai, K. Révész, R. E. Gyurcsányi and T. Mészáros, Anal. Methods, 2017, Advance Article , DOI: 10.1039/C7AY01777D

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