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Fluorescent sensors for sodium Ions


Sodium is a highly important metal in biological systems and its concentration in vivo is tightly regulated. However, fluctuation of sodium levels is still common and problematic, responsible for several physiological disorders and illnesses, including hypertension and cardiovascular diseases. Analytical methods for measuring sodium in biological samples are of great importance for disease diagnosis and for fundamental physiological studies. In this article, various types of fluorescent probes for Na+ based on small molecule chelators, proteins, and nucleic acids are reviewed, and each type has its advantages and disadvantages. While most efforts were made on developing small molecule based fluorescent sensors, recent developments in DNA-based sensing have also been quite promising with excellent sensitivity and selectivity. In particular, a few RNA-cleaving DNAzymes and an aptamer were reported with excellent selectivity for Na+ over K+ and Li+. Currently, the best sensors have a detection limit of ~0.1 mM Na+, and the dynamic range can cover its physiological concentration of ~140 mM in blood. The limitation of each type of probe is also discussed, and future research opportunities are speculated at the end.

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Publication details

The article was accepted on 30 Aug 2017 and first published on 04 Sep 2017

Article type: Critical Review
DOI: 10.1039/C7AY01708A
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Fluorescent sensors for sodium Ions

    G. Gao, Y. Cao, W. Liu, D. Li, W. Zhou and J. Liu, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY01708A

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