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Coupling solid-phase microextractions and surface-enhanced Raman scattering: towards a point-of-need tool for hepatic cancer screening

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Abstract

A method for performing rapid, highly portable immunoassays at low limits of detection (LoD) has been developed by combining solid-phase microextraction membranes, gold nanoparticle labels, and surface-enhanced Raman scattering. The capability of this methodology is demonstrated through measurements of alphafetoprotein, a marker used to screen individuals for hepatocellular carcinoma, directly from human serum at an estimated LoD of 3 pg mL−1 in ∼2 min.

Graphical abstract: Coupling solid-phase microextractions and surface-enhanced Raman scattering: towards a point-of-need tool for hepatic cancer screening

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Publication details

The article was received on 10 Jul 2017, accepted on 31 Jul 2017 and first published on 09 Aug 2017


Article type: Communication
DOI: 10.1039/C7AY01689A
Citation: Anal. Methods, 2017, Advance Article
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    Coupling solid-phase microextractions and surface-enhanced Raman scattering: towards a point-of-need tool for hepatic cancer screening

    J. H. Granger, A. Skuratovsky, M. D. Porter, Courtney L. Scaife, J. E. Shea, Q. Li and S. Wang, Anal. Methods, 2017, Advance Article , DOI: 10.1039/C7AY01689A

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