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Issue 32, 2017
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Coupling solid-phase microextractions and surface-enhanced Raman scattering: towards a point-of-need tool for hepatic cancer screening

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Abstract

A method for performing rapid, highly portable immunoassays at low limits of detection (LoD) has been developed by combining solid-phase microextraction membranes, gold nanoparticle labels, and surface-enhanced Raman scattering. The capability of this methodology is demonstrated through measurements of alphafetoprotein, a marker used to screen individuals for hepatocellular carcinoma, directly from human serum at an estimated LoD of 3 pg mL−1 in ∼2 min.

Graphical abstract: Coupling solid-phase microextractions and surface-enhanced Raman scattering: towards a point-of-need tool for hepatic cancer screening

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Publication details

The article was received on 10 Jul 2017, accepted on 31 Jul 2017 and first published on 09 Aug 2017


Article type: Communication
DOI: 10.1039/C7AY01689A
Citation: Anal. Methods, 2017,9, 4641-4646
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    Coupling solid-phase microextractions and surface-enhanced Raman scattering: towards a point-of-need tool for hepatic cancer screening

    J. H. Granger, A. Skuratovsky, M. D. Porter, Courtney L. Scaife, J. E. Shea, Q. Li and S. Wang, Anal. Methods, 2017, 9, 4641
    DOI: 10.1039/C7AY01689A

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