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Highly sensitive and label-free determination of thiram residue using surface-enhanced Raman spectroscopy (SERS) coupled with paper-based microfluidics

Abstract

In this study, a paper-based microfluidic surface-enhanced Raman spectroscopy (SERS) device was employed for the determination of trace level thiram. The paper-based microfluidic device was fabricated by cutting hydrophilic region which has been printed on the filter paper then pasting it onto the sellotape. The Au@Ag nanoparticles (NPs) were synthesized with 30 nm Au core and 7 nm Ag shell and used as SERS probe. The synthesized nanoparticles were dropped in one of the sample adding zones of paper-based microfluidics and thiram solution was dropped in another one. The solutions flowed through their own channels by capillary action and mixed together in reaction chamber. The optimization studies on the use of paper-based microfluidic devices were discussed. In SERS measurements, the intensity of the peak at 1143 cm-1 was highly sensitive, as a result it was chosen as an ideal peak for the quantitative analysis of concentration of thiram solution. The limit of detection (LOD) of thiram was as low as 1.0×10-9 mol/L, and the relative standard deviation (RSD) results analyzed at 10 random spots in SERS measurement area were all below 10%. The recovery values of thiram in adulterated tea samples were from 95% to 110%. All these results suggested that this proposed method is a prospective candidate for trace level thiram detection.

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Publication details

The article was received on 04 Jul 2017, accepted on 11 Oct 2017 and first published on 11 Oct 2017


Article type: Paper
DOI: 10.1039/C7AY01637A
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Highly sensitive and label-free determination of thiram residue using surface-enhanced Raman spectroscopy (SERS) coupled with paper-based microfluidics

    J. Zhu, Q. Chen, F. Kutsanedzie, M. Yang, Q. Ouyang and H. Jiang, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY01637A

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