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Detection of Lithium in Scalp Hair by Time-of-Flight Secondary Ion Mass Spectrometry with High Energy (MeV) Primary Ions

Abstract

An example of a low-Z element that has received increased attention in the material and medical sciences, is lithium. Lithium studies in biological systems may however present with numerous challenges due to the low concentration of this trace element in tissues that contain complex arrays of chemical compounds. Of the biological tissues for screening elements in the body, hair has become an attractive testing substrate since it stores higher concentrations of elements than blood or urine and also provides a longer diagnostic window. In this preliminary exploratory study, the application of a linear time-of-flight mass spectrometer for MeV secondary ion mass spectrometry (ToF MeV-SIMS) is presented for the simultaneous detection and spatial distribution mapping of lithium in single, unprocessed scalp hair across a longitudinal profile. The results of this study show the potential of ToF MeV-SIMS to provide a novel, time-limiting, and dual approach to profiling of lithium isotopes and mapping lithium in biological material as small as a single hair fibre. The significance of these preliminary results and future research are proposed.

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Publication details

The article was received on 03 Jul 2017, accepted on 26 Jul 2017 and first published on 27 Jul 2017


Article type: Communication
DOI: 10.1039/C7AY01616F
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Detection of Lithium in Scalp Hair by Time-of-Flight Secondary Ion Mass Spectrometry with High Energy (MeV) Primary Ions

    K. J. Cloete, B. Jenčič, Z. Smit, M. Kelemen, K. Mkentane and P. Pelicon, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY01616F

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