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Issue 36, 2017
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Biosensing methods for the detection of highly pathogenic avian influenza H5N1 and H7N9 viruses

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Abstract

The highly pathogenic avian influenza (HPAI) H5N1 and H7N9 viruses may lead to the next pandemic if human-to-human transmissibility is established because the host range restriction can be changed via virus mutations or reassortments. Therefore, effective and efficient detection methods are crucial for the early stage identification and surveillance of an outbreak of HPAI viruses. In this review, viral mutation and pathogenicity are briefly introduced first. Then, traditional detection methods, including virus isolation, immunoassays, and molecular biology methods, for H5N1 and H7N9 viruses are presented in detail. Finally, the state of the art in biosensing methods for the detection of H5N1 and H7N9 viruses is presented and discussed with an emphasis on advances made in biosensors. Future developments may make biosensing methods more accessible for low-cost and point-of-care application.

Graphical abstract: Biosensing methods for the detection of highly pathogenic avian influenza H5N1 and H7N9 viruses

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Publication details

The article was received on 28 Jun 2017, accepted on 30 Aug 2017 and first published on 31 Aug 2017


Article type: Critical Review
DOI: 10.1039/C7AY01585B
Citation: Anal. Methods, 2017,9, 5238-5248
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    Biosensing methods for the detection of highly pathogenic avian influenza H5N1 and H7N9 viruses

    Z. Li, Y. Fu, M. Liao and Y. Li, Anal. Methods, 2017, 9, 5238
    DOI: 10.1039/C7AY01585B

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