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Magnetic Tweezers for the Mechanical Research of DNAs at Single Molecule Level

Abstract

Biomechanical forces are involved in the physiological function of molecules. Single molecule magnetic tweezers have been developed and used to investigate the mechanical properties of individual biomolecules and their interactions. In this review, we will mainly review the application of magnetic tweezers for the mechanical research of DNAs at single molecule level. Firstly, we will briefly introduce the fundamentals and the categories of the instrument setups. Secondly, we will summarize and discuss the application of magnetic tweezers for the analysis of the mechanical properties of DNAs and the interactions between DNAs and different substances such as DNA-modifying enzymes, DNA structural proteins, cations, drugs, and organic chemicals. Finally, the advantages and disadvantages of magnetic tweezers for DNAs research are discussed. This work will provide important guides to the scientists in the field of DNA mechanics.

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Publication details

The article was received on 17 Jun 2017, accepted on 04 Sep 2017 and first published on 04 Sep 2017


Article type: Critical Review
DOI: 10.1039/C7AY01495C
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Magnetic Tweezers for the Mechanical Research of DNAs at Single Molecule Level

    Q. Xin, P. Li, Y. He, C. Shi, Y. Qiao, X. Bian, J. Su, R. Qiao, X. Zhou and J. Zhong, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY01495C

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