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A novel two-photon fluorescent probe for the selective detection of hydrogen peroxide based on a naphthalene derivative

Abstract

In this study, we report a novel two-photon fluorescent probe for monitoring hydrogen peroxide. Probe 1 consists of a naphthalene backbone and a boric acid ester which was used as a H2O2 reporter. The reaction of probe 1 with H2O2 triggers the cleavage of a boronate-based protecting group, and as a result, restores the fluorescence of compound 2. The probe can be applied to the quantification of hydrogen peroxide with a linear range covering from 1.0×10-6 to 2.5×10-4 mol•L-1. The detecting limit of probe 1 toward H2O2 was estimated as 0.7 µM. Furthermore, probe 1 was found to have a much higher selectivity for H2O2 than other reactive oxygen species and successfully applied to cell imaging of hydrogen peroxide with two-photon microscopy in live cells. The superior properties of the probe made it of great potential use in chemical and biological applications.

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Publication details

The article was received on 16 May 2017, accepted on 06 Jul 2017 and first published on 06 Jul 2017


Article type: Paper
DOI: 10.1039/C7AY01249G
Citation: Anal. Methods, 2017, Accepted Manuscript
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    A novel two-photon fluorescent probe for the selective detection of hydrogen peroxide based on a naphthalene derivative

    Q. Ma, X. Li, J. Zhang, X. Zhu, L. Zhou and H. Liu, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY01249G

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