Jump to main content
Jump to site search

Issue 28, 2017
Previous Article Next Article

Preparation and evaluation of β-cyclodextrin functionalized periodic mesoporous organosilica open tubular capillary columns

Author affiliations

Abstract

This study describes the preparation and electrochromatographic application of a chiral β-cyclodextrin functionalized periodic mesoporous organosilica bonded open tubular capillary column. The stationary phase (β-cyclodextrin functionalized period mesoporous organosilica; CD-PMO) was synthesized from bis(triethoxysilyl)ethane and N-[3-(trimethoxysilyl) propyl]ethylenediamine, followed by amino functionalization. The prepared CD-PMO was attached on the inner wall, which was modified by (3-glycidoxypropyl) methyldiethoxysilane, through a covalent bond. The stationary phase was characterized by Fourier-transform infrared (FT-IR) spectroscopy, Brunauer–Emmett–Teller (BET), and scanning electron microscopy (SEM). The electrochromatographic characterization of the stationary phase was performed using amino acid enantiomer derivatives. The effect of buffer pH and concentration on enantio-separation performance was also investigated. Good repeatability was gained, with relative standard deviation of the migration time and peak areas of less than 2.3% for run-to-run (n = 5), 4.0% for day-to-day (n = 5), and 5.0% for column-to-column (n = 3).

Graphical abstract: Preparation and evaluation of β-cyclodextrin functionalized periodic mesoporous organosilica open tubular capillary columns

Back to tab navigation

Publication details

The article was received on 05 May 2017, accepted on 17 Jun 2017 and first published on 20 Jun 2017


Article type: Paper
DOI: 10.1039/C7AY01155E
Citation: Anal. Methods, 2017,9, 4151-4156
  •   Request permissions

    Preparation and evaluation of β-cyclodextrin functionalized periodic mesoporous organosilica open tubular capillary columns

    D. Guo, M. Liu, S. Zhong, Y. Dong and X. Li, Anal. Methods, 2017, 9, 4151
    DOI: 10.1039/C7AY01155E

Search articles by author

Spotlight

Advertisements