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Secondary electrospray ionization proceeds via gas-phase chemical ionization

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Abstract

Our main goal was to gain further insights into the mechanism by which gas-phase analytes are ionized by interaction with plumes of electrospray solvents. We exposed target vapors to electrosprays of either water or deuterated water and mass analyzed them. Regardless of the solvent used, the analytes were detected in protonated form. In contrast, when the ionization chamber was humidified with deuterated water, the target vapors were detected in deuterated form. These observations suggest that either there is no interaction between analytes and electrospray charged droplets, or if there is any, a subsequent gas-phase ion–molecule reaction governs the process. Implications in practical examples such as breath analysis are discussed.

Graphical abstract: Secondary electrospray ionization proceeds via gas-phase chemical ionization

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Publication details

The article was received on 30 Apr 2017, accepted on 20 Jun 2017 and first published on 03 Jul 2017


Article type: Paper
DOI: 10.1039/C7AY01121K
Citation: Anal. Methods, 2017, Advance Article
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    Secondary electrospray ionization proceeds via gas-phase chemical ionization

    A. T. Rioseras, M. T. Gaugg and P. Martinez-Lozano Sinues, Anal. Methods, 2017, Advance Article , DOI: 10.1039/C7AY01121K

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