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Issue 26, 2017
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A new “on–off” fluorescent probe for the selective detection of copper ions in living cells

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Abstract

A new “on–off” fluorescent probe 4′,5′-bis((bis(thiophen-2-ylmethyl)amino)methyl)-2′,7′-dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (probe F) for the selective detection of copper ions was synthesized and characterized. The favorable features of the proposed probe included good selectivity, high sensitivity, excellent water solubility, low toxicity, and simple operation. In addition, the probe has good reusability and a wide range of applications. The linear range for copper ions was 0.005–100 μM with a limit of detection of 5 nM. Moreover, the experiments also showed that the probe was a reliable and specific probe for copper ion imaging in living cells.

Graphical abstract: A new “on–off” fluorescent probe for the selective detection of copper ions in living cells

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Publication details

The article was received on 27 Apr 2017, accepted on 03 Jun 2017 and first published on 05 Jun 2017


Article type: Paper
DOI: 10.1039/C7AY01097D
Citation: Anal. Methods, 2017,9, 3956-3961
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    A new “on–off” fluorescent probe for the selective detection of copper ions in living cells

    M. Wei, Y. Zhang, H. Li and S. Yao, Anal. Methods, 2017, 9, 3956
    DOI: 10.1039/C7AY01097D

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