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Issue 25, 2017
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Enzyme mediated assembly of gold nanoparticles for ultrasensitive colorimetric detection of hepatitis C virus antibody

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Abstract

Based on the aggregation of gold nanoparticles (AuNPs) induced by the acetylcholinesterase-catalyzed hydrolysis reaction, we have developed a novel highly sensitive enzyme mediated AuNP assembly based colorimetric method for the ultrasensitive detection of hepatitis C virus antibody (anti-HCV). The change of the AuNP color could be observed with the naked eye directly, and the detection limit achieved was as low as 10−13 g mL−1 anti-HCV, which was an improvement of 3 orders of magnitude compared to the conventional ELISA method. The developed method is sensitive and affordable, which will be useful for HCV disease monitoring and control in remote areas and resource-constrained countries.

Graphical abstract: Enzyme mediated assembly of gold nanoparticles for ultrasensitive colorimetric detection of hepatitis C virus antibody

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Publication details

The article was received on 26 Apr 2017, accepted on 25 May 2017 and first published on 25 May 2017


Article type: Paper
DOI: 10.1039/C7AY01086A
Citation: Anal. Methods, 2017,9, 3777-3781
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    Enzyme mediated assembly of gold nanoparticles for ultrasensitive colorimetric detection of hepatitis C virus antibody

    Y. Cheng, H. Tang and J. Jiang, Anal. Methods, 2017, 9, 3777
    DOI: 10.1039/C7AY01086A

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