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A gold nanoparticle-modified indium tin oxide microelectrode for in-channel amperometric detection in dual-channel microchip electrophoresis

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Abstract

A modified indium tin oxide (ITO) microelectrode detector integrated with a dual-channel polydimethylsiloxane (PDMS) microchip is proposed for in-channel amperometric detection in microchip electrophoresis (ME). The gold nanoparticle (GNP)-modified ITO-coated poly-ethylene terephthalate film electrode was fabricated via a photolithography process and direct electrochemical deposition. This electrode fabrication method reduced the cost of this microchip a lot. The electroplating conditions for the GNP-modified ITO electrode were optimized through evaluating the effect on the detection sensitivity and separation efficiency of a dual-channel ME system. Under the optimal conditions, the performance of the new ME amperometric detection system has been demonstrated by analyzing a mixture of p-aminophenol, o-aminophenol and m-aminophenol, which achieved the detection limits of 0.24 μM, 0.41 μM and 0.42 μM, respectively. Finally, the successful detection of antibiotics demonstrated the potential of this dual-channel microchip system for clinical application.

Graphical abstract: A gold nanoparticle-modified indium tin oxide microelectrode for in-channel amperometric detection in dual-channel microchip electrophoresis

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Publication details

The article was received on 16 Apr 2017, accepted on 12 Jun 2017 and first published on 20 Jun 2017


Article type: Paper
DOI: 10.1039/C7AY01008G
Citation: Anal. Methods, 2017, Advance Article
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    A gold nanoparticle-modified indium tin oxide microelectrode for in-channel amperometric detection in dual-channel microchip electrophoresis

    G. Zhu, Q. Song, W. Liu, X. Yan, J. Xiao and C. Chen, Anal. Methods, 2017, Advance Article , DOI: 10.1039/C7AY01008G

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