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Issue 19, 2017
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An azidocoumarin-based fluorescent probe for imaging lysosomal hydrogen sulfide in living cells

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Abstract

A commercially available fluorescent hydrogen sulfide (H2S) probe 7-azido-4-methylcoumarin (AzMC) was developed into its lysosome-targeted counterpart Lyso-C via a four-step synthetic approach. Lyso-C displayed fast response (within 5 min), excellent sensitivity (with a detection limit of 37 nM) and high selectivity toward H2S. More importantly, Lyso-C was successfully applied to imaging lysosomal H2S and showed potential capability to quantitatively detect H2S in living cells.

Graphical abstract: An azidocoumarin-based fluorescent probe for imaging lysosomal hydrogen sulfide in living cells

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Publication details

The article was received on 31 Mar 2017, accepted on 18 Apr 2017 and first published on 18 Apr 2017


Article type: Paper
DOI: 10.1039/C7AY00862G
Citation: Anal. Methods, 2017,9, 2859-2864
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    An azidocoumarin-based fluorescent probe for imaging lysosomal hydrogen sulfide in living cells

    Q. Xie, W. Liu, X. Liu, F. Ouyang, Y. Kuang and J. Jiang, Anal. Methods, 2017, 9, 2859
    DOI: 10.1039/C7AY00862G

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