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Issue 34, 2017
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Easy ambient sonic-spray ionization mass spectrometry for tissue imaging

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Abstract

Two spray-based ambient ionization methods, desorption electrospray ionization (DESI) and easy ambient sonic-spray ionization (EASI), have been successfully used to obtain tissue images of rat brain samples, for the first time, using both sources under their optimized conditions. Good ion images have been obtained by both techniques in MS and no significant difference was observed in the spray spot size. A comparative study between DESI and EASI on sensibility was also done and EASI was found to have similar or slightly higher sensitivity than DESI depending on the lipids interrogated (fatty acids, triacylglycerols and phospholipids). Thus, EASI can therefore be applied for tissue imaging particularly when the application of high voltage is impractical or undesirable.

Graphical abstract: Easy ambient sonic-spray ionization mass spectrometry for tissue imaging

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Publication details

The article was received on 31 Mar 2017, accepted on 13 May 2017 and first published on 15 Jun 2017


Article type: Paper
DOI: 10.1039/C7AY00858A
Citation: Anal. Methods, 2017,9, 5029-5036
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    Easy ambient sonic-spray ionization mass spectrometry for tissue imaging

    R. M. Alberici, P. H. Vendramini and M. N. Eberlin, Anal. Methods, 2017, 9, 5029
    DOI: 10.1039/C7AY00858A

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