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Enhancement of peroxidase-like activity of cerium-doped ferrite nanoparticle for colorimetric detection of H2O2 and Glucose

Abstract

In this report, ceria doped-ferrite nanoparticles (Ce-Fe3O4 NPs), a novel ceria nanostructure was proposed to have intrinsic peroxidase-like activity toward a classic peroxidase substrate in the presence of H2O2. Peroxidase-like activity of ceria originated from facile redox behavior (Ce4+ ↔Ce3+) as the catalytic center, thereby explaining the high performance of ferrite-Ceria as an artificial enzyme mimicking peroxidase. The as-prepared Ce-Fe3O4 NPs were firstly demonstrated to possess intrinsic peroxidase-like activity and could enhance the oxidization of the substrate 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of either added H2O2 or H2O2 produced by enzymatic oxidation of glucose, producing a blue product which can be seen by the naked eye. Based on that, we have successfully established a novel platform for colorimetric detection of H2O2 with the detection limit of 0.6 μM. Furthermore, the Ce-Fe3O4 NPs-based platform can also be used for high sensitivity and selectivity detection of glucose with a linear range of 10.0-150.0 μM and detection limit of 1.2 μM.

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Publication details

The article was received on 21 Mar 2017, accepted on 15 May 2017 and first published on 18 May 2017


Article type: Paper
DOI: 10.1039/C7AY00750G
Citation: Anal. Methods, 2017, Accepted Manuscript
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    Enhancement of peroxidase-like activity of cerium-doped ferrite nanoparticle for colorimetric detection of H2O2 and Glucose

    M. Hosseini, F. Sabet, H. Kahbbaz, M. Aghazadeh, F. Mizani and M. R. Ganjali, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY00750G

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