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Issue 23, 2017
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Enhancement of the peroxidase-like activity of cerium-doped ferrite nanoparticles for colorimetric detection of H2O2 and glucose

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Abstract

In this report, cerium doped-ferrite nanoparticles (Ce–Fe3O4 NPs), a novel ceria nanostructure, were proposed to have intrinsic peroxidase-like activity toward a classic peroxidase substrate in the presence of H2O2. The peroxidase-like activity of ceria originated from its facile redox behavior (Ce3+/Ce4+) as a catalytic center, thereby explaining the high performance of ferrite–ceria as an artificial enzyme mimicking peroxidase. The as-prepared Ce–Fe3O4 NPs were first demonstrated to possess intrinsic peroxidase-like activity, enhancing the oxidation of the substrate 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of either added H2O2 or H2O2 produced by the enzymatic oxidation of glucose, producing a blue product which could be seen by the naked eye. Based on this, we have successfully established a novel platform for the colorimetric detection of H2O2 with a detection limit of 0.6 μM. Furthermore, the Ce–Fe3O4 NP-based platform can also be used for highly sensitive and selective detection of glucose with a linear range of 5.0–150.0 μM and a detection limit of 1.2 μM.

Graphical abstract: Enhancement of the peroxidase-like activity of cerium-doped ferrite nanoparticles for colorimetric detection of H2O2 and glucose

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Publication details

The article was received on 21 Mar 2017, accepted on 15 May 2017 and first published on 18 May 2017


Article type: Paper
DOI: 10.1039/C7AY00750G
Citation: Anal. Methods, 2017,9, 3519-3524
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    Enhancement of the peroxidase-like activity of cerium-doped ferrite nanoparticles for colorimetric detection of H2O2 and glucose

    M. Hosseini, F. Sadat Sabet, H. Khabbaz, M. Aghazadeh, F. Mizani and M. R. Ganjali, Anal. Methods, 2017, 9, 3519
    DOI: 10.1039/C7AY00750G

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