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Issue 15, 2017
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Development of an analytical method for the determination of N-nitrosamines in tobacco by GC-NCD after solid phase extraction

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Abstract

In this paper an analytical method was developed for the determination of some tobacco specific N-nitrosamines (TSNAs) in cigarettes, and applied to cigarettes purchased in the city of Rio de Janeiro/RJ (Brazil). The analyte detection is based on the gas chromatography technique with a chemiluminescence detector (GC-NCD), while the extraction is based on two stages, the first is a cigarette leaching step, and the other is solid phase extraction of TSNAs from this leaching. The method presented an accuracy of 92 ± 18%; the precision was calculated using the coefficient of variation of a standard TSNA mix solution measured on 3 successive days and was in the range from 4.7 to 6.8%. The working range of all TSNAs was 50–700 ng mL−1, allowing the method to have LOQ values from 198.3 to 623.7.1 ng per cig. The method developed allowed determination of NNN, NAT, NNK and NAB in commercial cigarette samples.

Graphical abstract: Development of an analytical method for the determination of N-nitrosamines in tobacco by GC-NCD after solid phase extraction

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Publication details

The article was received on 03 Mar 2017, accepted on 11 Mar 2017 and first published on 14 Mar 2017


Article type: Paper
DOI: 10.1039/C7AY00577F
Citation: Anal. Methods, 2017,9, 2284-2289
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    Development of an analytical method for the determination of N-nitrosamines in tobacco by GC-NCD after solid phase extraction

    F. A. Soares, S. C. Chiapetta and W. F. Pacheco, Anal. Methods, 2017, 9, 2284
    DOI: 10.1039/C7AY00577F

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