Jump to main content
Jump to site search


Development of an analytical method for the determination of n-nitrosamines in tobacco by GC-NCD after solid phase extraction.

Abstract

In this paper an analytical method was developed for the determination of some tobacco specific n-nitrosamines (TSNA) in cigarettes, and applied to cigarettes purchased in the city of Rio de Janeiro / RJ (Brazil). The analyte detection is based on the gas chromatography technique with chemiluminescence detector (GC-NCD), while the extraction is based on two stages, the first is a cigarette leaching step, and another is a solid phase extraction of TSNA from this leaching. The method presented accuracy of 92 + 18%, the precision was calculated using the coefficient of variation of a standard TSNA mix solution measured on 3 successive days and was in the range from 4.7 to 6.8%. The working range of all TSNA was 50-700 ng mL-1, allowing the method to have LOQ values from 198.3 to 623.7.1 ng cig-1. The method developed allowed determination of NNN, NAT, NNK and NAB in commercial cigarette samples.

Back to tab navigation
Please wait while Download options loads

Publication details

The article was accepted on 11 Mar 2017, published on 14 Mar 2017 and first published online on 14 Mar 2017


Article type: Paper
DOI: 10.1039/C7AY00577F
Citation: Anal. Methods, 2017, Accepted Manuscript
  •   Request permissions

    Development of an analytical method for the determination of n-nitrosamines in tobacco by GC-NCD after solid phase extraction.

    F. A. Soares, S. C. Chiapetta and W. F. Pacheco, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY00577F

Search articles by author