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Issue 19, 2017
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Molecularly imprinted core–shell hybrid microspheres for the selective extraction of vanillin

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Abstract

Molecularly imprinted polymers (MIPs) with a core–shell structure for efficient, reliable, and selective extraction of vanillin via solid-phase extraction (SPE) and incubation methods were developed using a sol–gel process based on (3-aminopropyl)triethoxysilane (APTES) as the functional monomer, tetraethoxysilane (TEOS) as the cross-linker, and vanillin as the template. An inorganic core composed of porous (SM1) and non-porous (SM2) silica microspheres was prepared by co-condensation of TEOS and (3-aminopropyl)trimethoxysilane (APTMS) in a water-in-oil (W/O) macroemulsion. The thus synthesized materials were characterized in detail, and their molecular recognition properties and selectivity were demonstrated by evaluating their adsorption capacity and binding kinetics at imprinted (MIP) and non-imprinted (NIP) control materials. The proposed binding mechanism takes advantage of the amino groups associated with APTES interacting with the functional groups of the template molecules to form hydrogen-bonded complexes. Furthermore, synthesis conditions were optimized such that the imprinting efficiency and adsorption capacity were maximized. Finally, it was demonstrated via incubation experiments that the thus generated MIP core–shell hybrid microspheres provide rapid adsorption with high binding capacities (up to 5.64 mg g−1), excellent imprinting factors (IF up to 2.37), and exceptional reusability (reused >20 times).

Graphical abstract: Molecularly imprinted core–shell hybrid microspheres for the selective extraction of vanillin

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Publication details

The article was received on 21 Feb 2017, accepted on 03 Apr 2017 and first published on 03 Apr 2017


Article type: Paper
DOI: 10.1039/C7AY00461C
Citation: Anal. Methods, 2017,9, 2883-2889
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    Molecularly imprinted core–shell hybrid microspheres for the selective extraction of vanillin

    R. S. Fernandes, M. Dinc, I. M. Raimundo Jr and B. Mizaikoff, Anal. Methods, 2017, 9, 2883
    DOI: 10.1039/C7AY00461C

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