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A red fluorescent turn-on chemosensor for Al3+ based on a dimethoxy triphenylamine benzothiadiazole derivative with aggregation-induced emission

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Abstract

Aluminum is a known neurotoxin to organisms and believed to cause Alzheimer's disease, osteomalacia, and breast cancer. Therefore, effective tools for Al3+ recognition are in great demand. In this study, a new, sensitive, and highly selective red turn-on chemosensor (TB-COOH) for Al3+ was prepared by combining the dimethoxy triarylamine benzothiadiazole motif and carboxyl group, where the benzothiadiazole derivative functioned as an aggregation-induced emission (AIE) moiety and the carboxyl motif functioned as the recognition site for Al3+. This chemosensor showed significant fluorescence enhancement upon selective addition of Al3+ and a relatively low detection limit (1.5 × 10−7 M). The fluorescence turn-on mechanism was ascribed to the aggregation of TB-COOH after complexation with Al3+, which was confirmed by 1H NMR and FT-IR spectroscopies and scanning electronic microscopy. Furthermore, benefiting from its good water solubility and biocompatibility, imaging detection and real-time monitoring of Al3+ in living HeLa cells were successfully achieved.

Graphical abstract: A red fluorescent turn-on chemosensor for Al3+ based on a dimethoxy triphenylamine benzothiadiazole derivative with aggregation-induced emission

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Publication details

The article was received on 16 Jan 2017, accepted on 11 Apr 2017 and first published on 13 Apr 2017


Article type: Paper
DOI: 10.1039/C7AY00145B
Citation: Anal. Methods, 2017, Advance Article
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    A red fluorescent turn-on chemosensor for Al3+ based on a dimethoxy triphenylamine benzothiadiazole derivative with aggregation-induced emission

    N. Lu, T. Jiang, H. Tan, Y. Hang, J. Yang, J. Wang, X. Qu and J. Hua, Anal. Methods, 2017, Advance Article , DOI: 10.1039/C7AY00145B

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