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A red fluorescent turn-on chemosensor for Al3+ based on dimethoxy triphenylamine-benzothiadiazole derivative with aggregation-induced emission

Abstract

Aluminum is a known neurotoxin to organisms and believed to cause Alzheimer's disease, osteomalacia and breast cancer. Effective tools for Al3+ recognition are thus in great demand. In this paper, a new sensitive and highly selective red turn-on chemosensor (TB-COOH) for Al3+ was presented by combining the dimethoxy triarylamine- benzothiadiazole motif and carboxyl group, where the benzothiadiazole-derivative as aggregation-induced emission (AIE) moiety and the carboxyl motif functions as the recognition site with Al3+. It shows significant fluorescence enhancement upon addition of the selective Al3+ with a relatively low detection limit (1.5  10-7 M). The fluorescence turn on mechanism is ascribed to the aggregation of TB-COOH after complexation with Al3+, which has been confirmed by the 1H NMR, FT-IR spectra and scanning electronic microscope measurements. Furthermore, benefiting from its good water solubility and biocompatibility, imaging detection and real-time monitoring of Al3+ in living HeLa cells were successfully achieved.

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Publication details

The article was received on 16 Jan 2017, accepted on 11 Apr 2017 and first published on 13 Apr 2017


Article type: Paper
DOI: 10.1039/C7AY00145B
Citation: Anal. Methods, 2017, Accepted Manuscript
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    A red fluorescent turn-on chemosensor for Al3+ based on dimethoxy triphenylamine-benzothiadiazole derivative with aggregation-induced emission

    J. Hua, N. Lu, T. Jiang, H. Tan, Y. Hang, J. Yang, J. Wang and X. Qu, Anal. Methods, 2017, Accepted Manuscript , DOI: 10.1039/C7AY00145B

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