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Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

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Abstract

Native mass spectrometry can provide insight into the structure of macromolecular biological systems. As analytes under investigation get larger and more complex, instrument capabilities need to be advanced. Herein, modifications to an Orbitrap Q Exactive Plus mass spectrometer that increase signal intensity, mass resolution, and maximum m/z measurable are described.

Graphical abstract: Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

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Publication details

The article was received on 02 Oct 2017, accepted on 08 Nov 2017 and first published on 08 Nov 2017


Article type: Communication
DOI: 10.1039/C7AN01629H
Citation: Analyst, 2017, Advance Article
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    Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes

    K. L. Fort, M. van de Waterbeemd, D. Boll, M. Reinhardt-Szyba, M. E. Belov, E. Sasaki, R. Zschoche, D. Hilvert, A. A. Makarov and A. J. R. Heck, Analyst, 2017, Advance Article , DOI: 10.1039/C7AN01629H

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