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Recent advances on microfluidic technologies for single cell analysis

Abstract

The inherent heterogeneity in cell populations has become of great interest and importance as analytical techniques have improved over the past decades. With the advent of personalized medicine, understanding the impact of this heterogeneity has become an important challenge for the research community. Many different microfluidic approaches with varying levels of throughput and resolution exist to study single cell activity. In this review, we take a wide view of the recent microfluidic developments for single cell analysis based on microwell, microchamber, and droplet platforms. We cover physical, chemical, and molecular biology approaches for cellular and molecular analysis including newly emerging genome-wide analysis.

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Publication details

The article was received on 13 Aug 2017, accepted on 25 Oct 2017 and first published on 26 Oct 2017


Article type: Critical Review
DOI: 10.1039/C7AN01346A
Citation: Analyst, 2017, Accepted Manuscript
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    Recent advances on microfluidic technologies for single cell analysis

    T. Murphy, Q. Zhang, L. Naler, S. Ma and C. Lu, Analyst, 2017, Accepted Manuscript , DOI: 10.1039/C7AN01346A

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