A new tetraphenylethylene based AIE sensor with light-up and tunable measuring range for adenosine triphosphate in aqueous solution and in living cells

Guoyu Jiang; Wenping Zhu; Qingqing Chen; Aiping Shi; Yongquan Wu; Guanxin Zhang; Xun Li; Yongdong Li; Xiaolin Fan; Jianguo Wang

doi:10.1039/C7AN01336A

A new tetraphenylethylene based AIE sensor with light-up and tunable measuring range for adenosine triphosphate in aqueous solution and in living cells†

Guoyu Jiang,^a Wenping Zhu,^a Qingqing Chen,^a Aiping Shi,^a Yongquan Wu,

^a Guanxin Zhang,^b Xun Li,^a Yongdong Li,*^a Xiaolin Fan^a and Jianguo Wang

*^a

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* Corresponding authors

^a Key Laboratory of Organo-Pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, P. R. China
E-mail: wangjg@iccas.ac.cn
Tel: +86 797 8393536

^b Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

Abstract

An AIE based tetraphenylethylene derivative (TPPTPE) was synthesized for light-up sensing of ATP in aqueous solution. The measuring range for ATP can be tuned by varying the concentration of the TPPTPE. A one-step straightforward quantitative analysis of the ATP level in cell lysates can be realized using the TPPTPE. Moreover, the TPPTPE can be used for monitoring apyrase activity in aqueous solution and detecting ATP both in living cancer cell lines and in living normal cell lines.

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A new tetraphenylethylene based AIE sensor with light-up and tunable measuring range for adenosine triphosphate in aqueous solution and in living cells†

Abstract

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A new tetraphenylethylene based AIE sensor with light-up and tunable measuring range for adenosine triphosphate in aqueous solution and in living cells

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