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Development of a computationally-designed polymeric adsorbent specific for mycotoxin patulin

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Abstract

Patulin is a toxic compound which is found predominantly in apples affected by mould rot. Since apples and apple-containing products are a popular food for the elderly, children and babies, the monitoring of the toxin is crucial. This paper describes a development of a computationally-designed polymeric adsorbent for the solid-phase extraction of patulin, which provides an effective clean-up of the food samples and allows the detection and accurate quantification of patulin levels present in apple juice using conventional chromatography methods. The developed bespoke polymer demonstrates a quantitative binding towards the patulin present in undiluted apple juice. The polymer is inexpensive and easy to mass-produce. The contributing factors to the function of the adsorbent is a combination of acidic and basic functional monomers producing a zwitterionic complex in the solution that formed stronger binding complexes with the patulin molecule. The protocols described in this paper provide a blueprint for the development of polymeric adsorbents for other toxins or different food matrices.

Graphical abstract: Development of a computationally-designed polymeric adsorbent specific for mycotoxin patulin

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Publication details

The article was received on 04 Aug 2017, accepted on 06 Nov 2017 and first published on 06 Nov 2017


Article type: Paper
DOI: 10.1039/C7AN01294B
Citation: Analyst, 2017, Advance Article
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    Development of a computationally-designed polymeric adsorbent specific for mycotoxin patulin

    E. V. Piletska, D. Pink, K. Karim and S. A. Piletsky, Analyst, 2017, Advance Article , DOI: 10.1039/C7AN01294B

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