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Histological coherent Raman imaging: a prognostic review

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Abstract

Histopathology plays a central role in diagnosis of many diseases including solid cancers. Efforts are underway to transform this subjective art to an objective and quantitative science. Coherent Raman imaging (CRI), a label-free imaging modality with sub-cellular spatial resolution and molecule-specific contrast possesses characteristics which could support the qualitative-to-quantitative transition of histopathology. In this work we briefly survey major themes related to modernization of histopathology, review applications of CRI to histopathology and, finally, discuss potential roles for CRI in the transformation of histopathology that is already underway.

Graphical abstract: Histological coherent Raman imaging: a prognostic review

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Publication details

The article was received on 31 Jul 2017, accepted on 03 Oct 2017 and first published on 10 Oct 2017


Article type: Critical Review
DOI: 10.1039/C7AN01266G
Citation: Analyst, 2017, Advance Article
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    Histological coherent Raman imaging: a prognostic review

    M. T. Cicerone and C. H. Camp, Analyst, 2017, Advance Article , DOI: 10.1039/C7AN01266G

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