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Issue 20, 2017
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Mapping the interaction sites of Mucin 1 and DNA aptamer by atomic force microscopy

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Abstract

Mucin 1 (MUC1) is an attractive tumor marker for cancer diagnosis. An advanced atomic force microscopy (AFM) mode, peak-force tapping AFM with an aptamer functionalized tip, was introduced to map the specific interaction sites of an aptamer and MUC1. Single molecular force spectroscopy (SMFS) was used to investigate dynamic parameters of the aptamer–MUC1.

Graphical abstract: Mapping the interaction sites of Mucin 1 and DNA aptamer by atomic force microscopy

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Publication details

The article was received on 04 Jul 2017, accepted on 31 Aug 2017 and first published on 01 Sep 2017


Article type: Communication
DOI: 10.1039/C7AN01119A
Citation: Analyst, 2017,142, 3800-3804
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    Mapping the interaction sites of Mucin 1 and DNA aptamer by atomic force microscopy

    N. Wang, M. Zhang, X. Chen, X. Ma, C. Li, Z. Zhang and J. Tang, Analyst, 2017, 142, 3800
    DOI: 10.1039/C7AN01119A

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