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Titanium nanoparticles (TiO2) / Graphene oxide nanosheets (GO): an electrochemical sensing platform for the sensitive and simultaneous determination of benzocaine in the presence of antipyrine

Abstract

An effective electrochemical sensing platform for the simultaneous determination of benzocaine (BEN) and antipyrine (ANT) based upon graphene oxide nanosheets (GO) / titanium dioxide nanoparticles (TiO2) bulk modified carbon paste electrodes (GO-TiO2-CPE) is reported. Physicochemical characterization of the synthesized graphene oxide / titanium nanocomposite has been performed with X-ray diffraction (XRD) spectrometry, Fourier transform infrared (FT-IR) spectrometry and scanning electron microscopy (SEM). The GO-TiO2-CPE electrochemical sensing platform is found to exhibit linear ranges from 1.0 ×10-6 to 1.0 ×10-4 M and 1.20 ×10-8 to 8.0 ×10-5 M for BEN and ANT respectively. The GO-TiO2-CPE sensor is explored towards the analysis of BEN and ANT in oral fluid (saliva) and pharmaceutical products. The synergy of the graphene oxide nanosheets and titanium dioxide nanoparticles result in a dramatic enhancement in the sensitivity of the sensor through a combination of increased surface area and improved electron transfer kinetics compared to other electrode alternatives. The fabricated GO-TiO2-CPE is demonstrated to exhibit a high sensitivity, good stability towards the sensing of BEN and ANT and has potential to be used as a clinical assay and QA in pharmaceutical products.

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Publication details

The article was received on 01 Jul 2017, accepted on 28 Jul 2017 and first published on 10 Aug 2017


Article type: Paper
DOI: 10.1039/C7AN01101F
Citation: Analyst, 2017, Accepted Manuscript
  • Open access: Creative Commons BY license
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    Titanium nanoparticles (TiO2) / Graphene oxide nanosheets (GO): an electrochemical sensing platform for the sensitive and simultaneous determination of benzocaine in the presence of antipyrine

    C. E. Banks, M. A. Mohamed, C. Foster, S. Abdel Atty, H. merey and T. A. E. F. Mohamed, Analyst, 2017, Accepted Manuscript , DOI: 10.1039/C7AN01101F

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