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129Xe NMR-based sensors: biological applications and recent methods

Abstract

Xenon is a first-rate sensor of biological events, due to its large polarizable electron cloud inducing significant modification of NMR parameters through slight changes in its local environment. The use of xenon as a sensor is of increasing interest for sensitive magnetic resonance imaging, since its signal can be enhanced by several orders of magnitude, mainly by spin-exchange optical pumping. Furthermore xenon can be vectorized toward targets of interest by using functionalized host systems, enabling their detection at subnanomolar concentrations. Associated with a new generation of detection methods this gives rise to a powerful molecular imaging approach, where xenon can be delivered on purpose several times after introduction of the functionalized host system.

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Publication details

The article was received on 29 Jun 2017, accepted on 05 Aug 2017 and first published on 08 Aug 2017


Article type: Minireview
DOI: 10.1039/C7AN01088E
Citation: Analyst, 2017, Accepted Manuscript
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    129Xe NMR-based sensors: biological applications and recent methods

    E. Mari and P. Berthault, Analyst, 2017, Accepted Manuscript , DOI: 10.1039/C7AN01088E

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