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Issue 18, 2017
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129Xe NMR-based sensors: biological applications and recent methods

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Abstract

Xenon is a first-rate sensor of biological events owing to its large polarizable electron cloud, which induces significant modifications to NMR parameters in response to slight changes in its local environment. The use of xenon as a sensor is of increasing interest for sensitive magnetic resonance imaging, because its signal can be enhanced by several orders of magnitude, mainly by spin-exchange optical pumping. Furthermore, xenon can be vectorized toward targets of interest by using functionalized host systems, which enables their detection at sub-nanomolar concentrations. In association with a new generation of detection methods, this gives rise to a powerful molecular imaging approach, whereby xenon can be delivered systematically several times after the introduction of a functionalized host system.

Graphical abstract: 129Xe NMR-based sensors: biological applications and recent methods

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Publication details

The article was received on 29 Jun 2017, accepted on 05 Aug 2017 and first published on 08 Aug 2017


Article type: Minireview
DOI: 10.1039/C7AN01088E
Citation: Analyst, 2017,142, 3298-3308
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    129Xe NMR-based sensors: biological applications and recent methods

    E. Mari and P. Berthault, Analyst, 2017, 142, 3298
    DOI: 10.1039/C7AN01088E

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