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Exploiting the High Oxidation Potential of Carisoprodol on Boron-Doped Diamond Electrode: An improved method for its Simultaneous Determination with Acetaminophen and Caffeine

Abstract

A boron-doped diamond electrode (BDDE) was employed to development of a voltammetric method for the simultaneous determination of acetaminophen (ACT), caffeine (CAF) and carisoprodol (CAR) for the first time. CAR presents a high oxidation potential (2.0 V) and this electrode is suitable for this purpose due to its wide electrochemical potential window. The anodic peak potentials of ACT, CAF and CAR oxidation at BDDE were found to be 0.980 V, 1.50 V and 2.03 V (vs. Ag/AgCl (3.0 mol L–1 KCl)), respectively by cyclic voltammetry. After optimization of analytical conditions employing BDDE at pH 6.0 in Britton-Robinson buffer solution, square-wave voltammetry (SWV) was applied to the simultaneous determination, which the peak currents for the three molecules were found to vary linearly with their concentrations in the range of 2.99 – 283 µmol L–1 for ACT, 2.99 – 84.8 µmol L–1 for CAF and 19.9 – 207 µmol L–1 for CAR, with detection limits of 2.56 µmol L–1, 2.57 µmol L–1, 10.4 µmol L–1, respectively. The proposed method was employed for the simultaneous determination of the three molecules in pharmaceutical formulations and the results were successfully validated with comparative spectrophotometric method. The use of BDDE showed advantages, such as low cost, suitable linearity for simultaneous quantification in real samples, without adsorption problems, rapidity, excellent reproducibility and environmentally friendly. This electrode represents a suitable electrochemical sensor for routine analysis of these drugs.

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Publication details

The article was received on 27 Jun 2017, accepted on 30 Jul 2017 and first published on 02 Aug 2017


Article type: Paper
DOI: 10.1039/C7AN01074E
Citation: Analyst, 2017, Accepted Manuscript
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    Exploiting the High Oxidation Potential of Carisoprodol on Boron-Doped Diamond Electrode: An improved method for its Simultaneous Determination with Acetaminophen and Caffeine

    A. P. P. Eisele, C. F. Valezi and E. R. Sartori, Analyst, 2017, Accepted Manuscript , DOI: 10.1039/C7AN01074E

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