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Smartphone Readable Colorimetric Sensing Platform for Rapid Multiple Proteins Detection

Abstract

A simple, visible and smartphone readable strategy has been proposed for the sensitive detection and discrimination of multiple proteins. By employing five different concentrations of NaCl salt, AuNPs exhibited different aggregation behavior for different proteins because of differential ions strength, leading to diverse color changes. The sensing system could not only discriminate twelve proteins at the concentration of 50 nM in aqueous solution, but also these proteins at 200 nM in the presence of human urine with accuracy of 100%. More importantly, based on the theory of chromatics, we could directly read out the color value using a smartphone to distinguish twelve proteins, pure Lys and HSA at various concentrations, and the mixture of these two proteins in the presence of human urine with no confusion after a hierarchical clustering analysis (HCA). The inexpensive and convenient colorimetric sensor array by using the ubiquitous smartphone for signal readout will has great potential for the point-of-care diagnosis without additional devices.

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Publication details

The article was received on 14 Jun 2017, accepted on 05 Jul 2017 and first published on 07 Jul 2017


Article type: Paper
DOI: 10.1039/C7AN00990A
Citation: Analyst, 2017, Accepted Manuscript
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    Smartphone Readable Colorimetric Sensing Platform for Rapid Multiple Proteins Detection

    F. Wang, Y. Lu, J. Yang, Y. Chen, W. Jing, L. He and Y. liu, Analyst, 2017, Accepted Manuscript , DOI: 10.1039/C7AN00990A

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