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Effectively enhancing the enantioseparation ability of β-cyclodextrin derivatives by de novo design and molecular modeling

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Abstract

Rational engineering of native β-CD as an ideal chiral selector for a definite analyte in capillary electrophoresis represents a challenge in separation science. Herein, a rational and systematic strategy that combines the de novo design and molecular modeling is firstly described to expedite the manipulation and selection of effective selector for enantioseparation in capillary electrophoresis. Using β-adrenoreceptor agonists as model analytes, we demonstrate how this strategy efficiently improves the enantiorecognition in chiral discrimination sites of inclusion complexes. The evolved β-CD derivative could be utilized as a chiral receptor to achieve the effective enantioseparation (Rs > 1.5) of racemic β-adrenoreceptor agonists. We highlight a novel strategy for efficiently and rapidly manipulating native CD based on the characteristics of analyte so as to gain an excellent chiral selector.

Graphical abstract: Effectively enhancing the enantioseparation ability of β-cyclodextrin derivatives by de novo design and molecular modeling

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Publication details

The article was received on 14 Jun 2017, accepted on 09 Aug 2017 and first published on 15 Aug 2017


Article type: Paper
DOI: 10.1039/C7AN00986K
Citation: Analyst, 2017, Advance Article
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    Effectively enhancing the enantioseparation ability of β-cyclodextrin derivatives by de novo design and molecular modeling

    L. Li, C. Wu, Y. Ma, S. Zhou, Z. Li and T. Sun, Analyst, 2017, Advance Article , DOI: 10.1039/C7AN00986K

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