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Issue 23, 2017
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Recent advances in phosphoproteomics and application to neurological diseases

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Abstract

Phosphorylation has an incredible impact on the biological behavior of proteins, altering everything from intrinsic activity to cellular localization and complex formation. It is no surprise then that this post-translational modification has been the subject of intense study and that, with the advent of faster, more accurate instrumentation, the number of large-scale mass spectrometry-based phosphoproteomic studies has swelled over the past decade. Recent developments in sample preparation, phosphorylation enrichment, quantification, and data analysis strategies permit both targeted and ultra-deep phosphoproteome profiling, but challenges remain in pinpointing biologically relevant phosphorylation events. We describe here technological advances that have facilitated phosphoproteomic analysis of cells, tissues, and biofluids and note applications to neuropathologies in which the phosphorylation machinery may be dysregulated, much as it is in cancer.

Graphical abstract: Recent advances in phosphoproteomics and application to neurological diseases

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Publication details

The article was received on 13 Jun 2017, accepted on 17 Oct 2017 and first published on 20 Oct 2017


Article type: Critical Review
DOI: 10.1039/C7AN00985B
Citation: Analyst, 2017,142, 4373-4387
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    Recent advances in phosphoproteomics and application to neurological diseases

    J. V. Arrington, C. Hsu, S. G. Elder and W. Andy Tao, Analyst, 2017, 142, 4373
    DOI: 10.1039/C7AN00985B

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