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Issue 17, 2017
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Enzyme-free, signal-amplified nucleic acid circuits for biosensing and bioimaging analysis

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Abstract

Enzyme-free, signal-amplified nucleic acid circuits utilize programmed assembly reactions between nucleic acid substrates to transduce a chemical input into an amplified detection signal. These circuits have shown great potential for developing biosensors for high-sensitivity and high-selectivity detection of varying targets including nucleic acids, small molecules and proteins in vitro and for high-contrast in situ visualization and imaging of these targets in tissues and living cells. We review the background of the enzyme-free, signal-amplified nucleic acid circuits, including their mechanism, significance, types and development. We also review current applications of these circuits for biosensors and bioimaging.

Graphical abstract: Enzyme-free, signal-amplified nucleic acid circuits for biosensing and bioimaging analysis

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Publication details

The article was received on 10 Jun 2017, accepted on 03 Jul 2017 and first published on 06 Jul 2017


Article type: Critical Review
DOI: 10.1039/C7AN00967D
Citation: Analyst, 2017,142, 3048-3061
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    Enzyme-free, signal-amplified nucleic acid circuits for biosensing and bioimaging analysis

    J. Chen, L. Tang, X. Chu and J. Jiang, Analyst, 2017, 142, 3048
    DOI: 10.1039/C7AN00967D

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