Jump to main content
Jump to site search


Enzyme-free, signal-amplified nucleic acid circuits for biosensing and bioimaging analysis

Author affiliations

Abstract

Enzyme-free, signal-amplified nucleic acid circuits utilize programmed assembly reactions between nucleic acid substrates to transduce a chemical input into an amplified detection signal. These circuits have shown great potential for developing biosensors for high-sensitivity and high-selectivity detection of varying targets including nucleic acids, small molecules and proteins in vitro and for high-contrast in situ visualization and imaging of these targets in tissues and living cells. We review the background of the enzyme-free, signal-amplified nucleic acid circuits, including their mechanism, significance, types and development. We also review current applications of these circuits for biosensors and bioimaging.

Graphical abstract: Enzyme-free, signal-amplified nucleic acid circuits for biosensing and bioimaging analysis

Back to tab navigation

Publication details

The article was received on 10 Jun 2017, accepted on 03 Jul 2017 and first published on 06 Jul 2017


Article type: Critical Review
DOI: 10.1039/C7AN00967D
Citation: Analyst, 2017, Advance Article
  •   Request permissions

    Enzyme-free, signal-amplified nucleic acid circuits for biosensing and bioimaging analysis

    J. Chen, L. Tang, X. Chu and J. Jiang, Analyst, 2017, Advance Article , DOI: 10.1039/C7AN00967D

Search articles by author

Spotlight

Advertisements