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Issue 15, 2017
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Hemin/Au nanorods/self-doped TiO2 nanowires as a novel photoelectrochemical bioanalysis platform

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Abstract

As a recently developed detection technique, photoelectrochemical (PEC) measurement has received extensive attention. However, owing to the lack of a comprehensive approach to engineer the photo-generated carriers, the performance is still limited. As an example, a significant use of PEC measurement might be in understanding the roles of glutathione in physiological and pathological processes. Here, we developed a new approach for engineering the photo-generated carriers with the aid of the synergic effect of self-doping, surface plasmon resonance, electrical field amplification effect, etc. Thus, a highly sensitive multicomponent PEC platform has been developed, in which Au nanorods are decorated on the surface of self-doped TiO2 nanowires, followed by surface receptor functionalization with hemin for capturing glutathione. The synergic effect effectively increases generation, separation and transfer kinetics of the photo-generated carriers, which can be further increased by using a mixture of Au nanorods with different aspect ratios to tune the absorption wavelength to the entire UV-visible region. As a result, this system exhibits a broad linear range from 10 nM to 17.5 μM and low detection limit down to 8.6 nM for detecting glutathione, about 1–2 orders of magnitude lower than most existing PEC sensors.

Graphical abstract: Hemin/Au nanorods/self-doped TiO2 nanowires as a novel photoelectrochemical bioanalysis platform

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Publication details

The article was received on 11 May 2017, accepted on 28 Jun 2017 and first published on 28 Jun 2017


Article type: Paper
DOI: 10.1039/C7AN00783C
Citation: Analyst, 2017,142, 2805-2811
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    Hemin/Au nanorods/self-doped TiO2 nanowires as a novel photoelectrochemical bioanalysis platform

    Z. Wang, M. Cao, L. Yang, D. Liu and D. Wei, Analyst, 2017, 142, 2805
    DOI: 10.1039/C7AN00783C

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