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Raman Endoscopy for Monitoring Anticancer Drug Treatment of Colorectal Tumors in Live Mice

Abstract

A miniaturized Raman endoscope (mRE) system was employed to study the effects of anticancer treatment on colorectal tumors in a live murine model. The endoscope is narrow enough to observe the inside of the mouse colon under anesthesia. It has a channel for a ball lens mounted on a hollow fiber Raman probe (BHRP) to measure any targeted point under the visual control of the endoscope. Colorectal cancer tissue was observed to study alterations of the tissue in response to anticancer drug treatment. Three anticancer drugs, 5-fluorouracil (5-FU), cisplatin (CDDP), and docetaxel were employed. Although no alteration was recognized in the endoscopic visual observations at 2 weeks after the drug treatments, the Raman spectra obtained in the live mouse colon indicated that molecular changes of lipids and proteins were observed. This study demonstrates that in situ Raman analysis is highly sensitive in detecting the effects of anticancer drugs.

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Publication details

The article was received on 01 May 2017, accepted on 04 Aug 2017 and first published on 07 Aug 2017


Article type: Paper
DOI: 10.1039/C7AN00720E
Citation: Analyst, 2017, Accepted Manuscript
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    Raman Endoscopy for Monitoring Anticancer Drug Treatment of Colorectal Tumors in Live Mice

    A. Taketani, B. Andriana, H. Matsuyoshi and H. Sato, Analyst, 2017, Accepted Manuscript , DOI: 10.1039/C7AN00720E

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