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Fast, highly sensitive and selective assay of iodide ions with single-stranded DNA-templated copper nanoparticles as a fluorescent probe for its application in Kunming mice samples

Abstract

The development of fast, sensitive, selective and flexible methods for the detection of iodide is highly demanded and of great significance. In this work, single-stranded DNA-templated copper nanoparticles (ssDNA-CuNPs) generated by sodium ascorbate reduction of Cu2+ along single-stranded DNA of poly-T were utilized as a fluorescent probe for determination of iodide ions (I-). The detection scheme is based on the instant quenching of the fluorescence of ssDNA-CuNPs by iodide ion. I−can be quantified in the concentration range from 0.050 to 40 μM and from 40 to 80 μM, and the limit of detection is as low as 15 nM. This method provides a simple and convenient strategy for biochemical assay of I−, which is also helpful to the point of early diagnosis of related diseases. The establishment of the low cost and fast detection method would be particularly important in developing countries where medical supplies are lacking.

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Supplementary files

Publication details

The article was received on 08 Apr 2017, accepted on 08 Jun 2017 and first published on 08 Jun 2017


Article type: Paper
DOI: 10.1039/C7AN00595D
Citation: Analyst, 2017, Accepted Manuscript
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    Fast, highly sensitive and selective assay of iodide ions with single-stranded DNA-templated copper nanoparticles as a fluorescent probe for its application in Kunming mice samples

    Z. Chen, Y. Niu, G. Cheng, L. Tong, G. Zhang, F. Cai, T. Chen, B. Liu and B. Tang, Analyst, 2017, Accepted Manuscript , DOI: 10.1039/C7AN00595D

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