Jump to main content
Jump to site search


Mass spectrometry imaging for clinical research – latest developments, applications, and current limitations

Author affiliations

Abstract

Mass spectrometry is being used in many clinical research areas ranging from toxicology to personalized medicine. Of all the mass spectrometry techniques, mass spectrometry imaging (MSI), in particular, has continuously grown towards clinical acceptance. Significant technological and methodological improvements have contributed to enhance the performance of MSI recently, pushing the limits of throughput, spatial resolution, and sensitivity. This has stimulated the spread of MSI usage across various biomedical research areas such as oncology, neurological disorders, cardiology, and rheumatology, just to name a few. After highlighting the latest major developments and applications touching all aspects of translational research (i.e. from early pre-clinical to clinical research), we will discuss the present challenges in translational research performed with MSI: data management and analysis, molecular coverage and identification capabilities, and finally, reproducibility across multiple research centers, which is the largest remaining obstacle in moving MSI towards clinical routine.

Graphical abstract: Mass spectrometry imaging for clinical research – latest developments, applications, and current limitations

Back to tab navigation

Publication details

The article was received on 05 Apr 2017, accepted on 11 Jun 2017 and first published on 12 Jun 2017


Article type: Critical Review
DOI: 10.1039/C7AN00565B
Citation: Analyst, 2017, Advance Article
  •   Request permissions

    Mass spectrometry imaging for clinical research – latest developments, applications, and current limitations

    P. Vaysse, R. M. A. Heeren, T. Porta and B. Balluff, Analyst, 2017, Advance Article , DOI: 10.1039/C7AN00565B

Search articles by author

Spotlight

Advertisements