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Thiol–ene micropillar array electrospray ionization platform for zeptomole level bioanalysis

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Abstract

A micropillar array electrospray ionization (μPESI) platform fabricated from thiol–enes with 56 individual polyethylene glycol coated μPESI chips for bioanalytical mass spectrometry is introduced. Bioanalysis capability is shown by measurement of a protein, a protein digest and a cell lysate sample. The thiol–ene polyethylene glycol (PEG) coated μPESI chip allows the use of a wide range of aqueous–organic solvent compositions and provides a detection limit at 60 zeptomole level (6 × 10−20 mol) for a peptide standard.

Graphical abstract: Thiol–ene micropillar array electrospray ionization platform for zeptomole level bioanalysis

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Publication details

The article was received on 31 Mar 2017, accepted on 02 Jun 2017 and first published on 15 Jun 2017


Article type: Communication
DOI: 10.1039/C7AN00544J
Citation: Analyst, 2017, Advance Article
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    Thiol–ene micropillar array electrospray ionization platform for zeptomole level bioanalysis

    K. Lipponen, S. Tähkä, T. Sikanen, V. Jokinen, A. Tatikonda, S. Franssila, R. Kostiainen and T. Kotiaho, Analyst, 2017, Advance Article , DOI: 10.1039/C7AN00544J

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