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Sensitive determination of chlorogenic acid in pharmaceutical products based on the decoration of 3D macroporous carbon with Au nanoparticles via polyoxometalates

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Abstract

A simple and sensitive electrochemical sensor is constructed for the detection of chlorogenic acid (CGA) based on Au nanoparticles (NPs)/polyoxometalates/3D macroporous carbon (Au-POMs-MPC). Serving as both a reducing and stabilizing agent, the Keggin-type POM, H3PW12O40, is used for the synthesis of stable colloidal Au NPs and then used to link them to MPC at a mild temperature. Because of the unique structural properties and synergetic catalytic effect, Au-POMs-MPC can be developed as an effective sensing platform for the detection of CGA, which showed high activity and excellent analytical performance towards CGA, such as a wide linear range of 2.28 nM–3.24 μM, a high sensitivity of 30 554.71 μA mM−1, and a low limit of detection of 2.15 nM. Importantly, the successfully fabricated Au-POMs-MPC device accurately measured the amount of CGA in pharmaceutical samples.

Graphical abstract: Sensitive determination of chlorogenic acid in pharmaceutical products based on the decoration of 3D macroporous carbon with Au nanoparticles via polyoxometalates

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Publication details

The article was received on 22 Mar 2017, accepted on 31 May 2017 and first published on 31 May 2017


Article type: Paper
DOI: 10.1039/C7AN00493A
Citation: Analyst, 2017, Advance Article
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    Sensitive determination of chlorogenic acid in pharmaceutical products based on the decoration of 3D macroporous carbon with Au nanoparticles via polyoxometalates

    T. Zhang, M. Liu, Q. Zhang, Y. Wang, X. Kong, L. Wang, H. Wang and Y. Zhang, Analyst, 2017, Advance Article , DOI: 10.1039/C7AN00493A

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