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Pulsed valve matrix-assisted ionization

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We have developed a new ionization approach for matrix-assisted ionization with high temporal resolution using an electrically actuated pulsed valve. Matrix and analyte samples are deposited on a thin metal foil and placed at the inlet of an ambient ionization mass spectrometer. When the pulsed valve is actuated, a short puff of high pressure gas impinges on the foil and ejects particulate from the sample on the opposite side. Highly charged ions are formed from the particles at the mass spectrometer inlet. Using this source, multiply charged protein ions are produced within a selectable 4 second time window.

Graphical abstract: Pulsed valve matrix-assisted ionization

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Publication details

The article was received on 21 Mar 2017, accepted on 13 Apr 2017 and first published on 19 Apr 2017

Article type: Communication
DOI: 10.1039/C7AN00489C
Citation: Analyst, 2017, Advance Article
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    Pulsed valve matrix-assisted ionization

    B. Banstola and Kermit. K. Murray, Analyst, 2017, Advance Article , DOI: 10.1039/C7AN00489C

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