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Antineoplastic drugs and their analysis: a state of the art review

Abstract

The number of patients suffering from a cancer is constantly increasing and, consequently, the number of chemotherapies administered follows the same trend. Given the high reactivity and toxicity of the antineoplastic drugs, analytical methods are required in all the pharmaceutical fields: from drug development to their elimination in wastewater treatment plant, including formulation quality control, environment and human exposure as well as therapeutic drug monitoring. The aim of this paper is to provide an overview of the analytical methods available for the determination of antineoplastic drugs in different matrices such as pharmaceutical formulations, biological and environmental samples. The applicability and performance of the reported methods will be critically discussed, with a special focus on the most commonly used antineoplastic drugs. Only conventional compounds and small molecules of targered therapy will be considered in the present review.

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Publication details

The article was received on 02 Mar 2017, accepted on 10 May 2017 and first published on 15 May 2017


Article type: Critical Review
DOI: 10.1039/C7AN00367F
Citation: Analyst, 2017, Accepted Manuscript
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    Antineoplastic drugs and their analysis: a state of the art review

    N. GUICHARD, D. Guillarme, P. Bonnabry and S. Fleury-Souverain, Analyst, 2017, Accepted Manuscript , DOI: 10.1039/C7AN00367F

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