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Toward artifact-free data in Hadamard transform-based double multiplexing of ion mobility-Orbitrap mass spectrometry

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Abstract

The integration of ion mobility spectrometry (IMS) with a trap-based mass spectrometer (MS) such as Orbitrap using the dual gate approach suffers from low duty cycle. Efforts to improve the duty cycle involve the utilization of Hadamard transform-based double multiplexing which significantly improves the signal-to-noise ratio and duty cycle of the ion mobility-Orbitrap mass spectrometry (IM-Orbitrap MS) platform. However, artifacts and noise in the demultiplexed data significantly reduce the data quality and negate the benefits of multiplexing. We propose a new approach that identifies the true IM peaks and helps in eliminating the artifacts in the demultiplexed data leading to a decrease in false identifications in subsequent data processing. After the application of the algorithm, the quality of the IM-Orbitrap MS measurements was greatly improved because of the reduction in artifacts.

Graphical abstract: Toward artifact-free data in Hadamard transform-based double multiplexing of ion mobility-Orbitrap mass spectrometry

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Publication details

The article was received on 18 Feb 2017, accepted on 29 Mar 2017 and first published on 10 Apr 2017


Article type: Paper
DOI: 10.1039/C7AN00289K
Citation: Analyst, 2017, Advance Article
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    Toward artifact-free data in Hadamard transform-based double multiplexing of ion mobility-Orbitrap mass spectrometry

    M. Tummalacherla, S. V. B. Garimella, S. A. Prost and Y. M. Ibrahim, Analyst, 2017, Advance Article , DOI: 10.1039/C7AN00289K

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