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An innovative chemical strategy for PCR-free genetic detection of pathogens by an integrated electrochemical biosensor

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Abstract

An innovative chemical strategy integrated in a miniaturized electrochemical device was developed for sensitive detection of a pathogen genome (HBV virus) without any amplification step. The results show a limit of detection comparable to the standard qRT-PCR method (20 copies per reaction), paving the way to future development of genetic PoC devices addressing automatized and low-cost molecular diagnostics.

Graphical abstract: An innovative chemical strategy for PCR-free genetic detection of pathogens by an integrated electrochemical biosensor

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Publication details

The article was received on 04 Feb 2017, accepted on 30 Mar 2017 and first published on 06 Apr 2017


Article type: Communication
DOI: 10.1039/C7AN00202E
Citation: Analyst, 2017, Advance Article
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    An innovative chemical strategy for PCR-free genetic detection of pathogens by an integrated electrochemical biosensor

    S. Petralia, E. L. Sciuto, M. L. Di Pietro, M. Zimbone, M. G. Grimaldi and S. Conoci, Analyst, 2017, Advance Article , DOI: 10.1039/C7AN00202E

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