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Issue 9, 2017
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Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

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Abstract

Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.

Graphical abstract: Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

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Publication details

The article was received on 13 Jan 2017, accepted on 11 Mar 2017 and first published on 13 Mar 2017


Article type: Communication
DOI: 10.1039/C7AN00076F
Citation: Analyst, 2017,142, 1429-1433
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    Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

    D. E. Korenchan, C. Taglang, C. von Morze, J. E. Blecha, J. W. Gordon, R. Sriram, P. E. Z. Larson, D. B. Vigneron, H. F. VanBrocklin, J. Kurhanewicz, D. M. Wilson and R. R. Flavell, Analyst, 2017, 142, 1429
    DOI: 10.1039/C7AN00076F

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