Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

D. E. Korenchan; C. Taglang; C. von Morze; J. E. Blecha; J. W. Gordon; R. Sriram; P. E. Z. Larson; D. B. Vigneron; H. F. VanBrocklin; J. Kurhanewicz; D. M. Wilson; R. R. Flavell

doi:10.1039/C7AN00076F

Dicarboxylic acids as pH sensors for hyperpolarized ¹³C magnetic resonance spectroscopic imaging†

D. E. Korenchan,

^ab C. Taglang,^b C. von Morze,^b J. E. Blecha,^b J. W. Gordon,^b R. Sriram,^b P. E. Z. Larson,^ab D. B. Vigneron,^b H. F. VanBrocklin,^b J. Kurhanewicz,^ab D. M. Wilson^b and R. R. Flavell

*^b

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^a UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA

^b Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
E-mail: Robert.flavell@ucsf.edu

Abstract

Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-¹³C,D₁₀]diethylmalonic acid, which exhibits a large pH-dependent ¹³C chemical shift over the physiological range. We demonstrate that co-polarization with [1-¹³C,D₉]tert-butanol accurately measures pH via¹³C NMR and magnetic resonance spectroscopic imaging in phantoms.

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Dicarboxylic acids as pH sensors for hyperpolarized ¹³C magnetic resonance spectroscopic imaging†

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Dicarboxylic acids as pH sensors for hyperpolarized ¹³C magnetic resonance spectroscopic imaging

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