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Issue 7, 2017
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New frontiers for mass spectrometry based upon structures for lossless ion manipulations

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Abstract

Structures for lossless ion manipulations (SLIM) provide a new paradigm for efficient, complex and extended gas phase ion manipulations. SLIM are created from electric fields generated by the application of DC and RF potentials to arrays of electrodes patterned on two parallel surfaces. The electric fields provide lossless ion manipulations, including effective ion transport and storage. SLIM modules have been developed using both constant and oscillatory electric fields (e.g. traveling waves) to affect the ion motion. Ion manipulations demonstrated to date with SLIM include: extended trapping, ion selection, ion dissociation, and ion mobility spectrometry (IMS) separations achieving unprecedented ultra high resolution. SLIM thus provide the basis for previously impractical manipulations, such as very long path length ion mobility separations where ions traverse a serpentine path multiple times, as well as new capabilities that extend the utility of these developments based on temporal and spatial compression of ion mobility separations and other ion distributions. The evolution of SLIM devices developed over the last three years is reviewed and we provide examples of various ion manipulations performed, and briefly discuss potential applications and new directions.

Graphical abstract: New frontiers for mass spectrometry based upon structures for lossless ion manipulations

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Publication details

The article was received on 05 Jan 2017, accepted on 25 Feb 2017 and first published on 03 Mar 2017


Article type: Minireview
DOI: 10.1039/C7AN00031F
Citation: Analyst, 2017,142, 1010-1021
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    New frontiers for mass spectrometry based upon structures for lossless ion manipulations

    Y. M. Ibrahim, A. M. Hamid, L. Deng, S. V. B. Garimella, I. K. Webb, E. S. Baker and R. D. Smith, Analyst, 2017, 142, 1010
    DOI: 10.1039/C7AN00031F

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